Randomized Clinical Trials of Nonpharmacological Treatments by Isabelle Boutron,Philippe Ravaud,David Moher PDF

By Isabelle Boutron,Philippe Ravaud,David Moher

ISBN-10: 1420088017

ISBN-13: 9781420088014

Nonpharmacological remedies comprise a wide selection of remedies similar to surgical procedure, technical approaches, implantable and non-implantable units, rehabilitation, psychotherapy, and behavioral interventions. not like pharmacological remedies, those don't have any particular requisites for approval. accordingly, they are often greatly proposed in scientific perform yet would possibly not were safely evaluated. this case is a vital barrier for the evaluate of the precious results of those remedies and the behavior of scientific trials. Randomized medical Trials of Nonpharmacologic Treatments makes a speciality of the equipment for assessing nonpharmacological remedies, highlighting particular concerns and trial layout.


  • Chapters written by means of overseas specialists within the field

  • Highlights particular matters in assessing nonpharmacological remedies in trials including:

    • how to beat the problems of blinding sufferers, care prone, and consequence assessors

    • the complexity of the intervention, the educational curve, and the clustering influence

    • placebos that may be used

    • issues of assessing damage and assessing the applicability of trials

  • Presents numerous trial designs for nonpharmacological treatments—including cluster randomized managed trials, expertise-based trials, pragmatic trials, and nonrandomized trials.

  • Provides a number of examples of the making plans, behavior, analyses, and reporting of trials in several fields, together with surgical procedure, technical interventions, scientific units, rehabilitation, psychotherapy, and behavioral interventions.

Providing functional examples that underline those concerns and suggestions, this booklet is likely one of the first to completely discover this subject, discussing numerous different types of remedies, from surgeries to psychotherapy.

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Randomized Clinical Trials of Nonpharmacological Treatments (Chapman & Hall/CRC Biostatistics Series) by Isabelle Boutron,Philippe Ravaud,David Moher

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