Download PDF by Alex Dmitrienko,Ajit C. Tamhane,Frank Bretz: Multiple Testing Problems in Pharmaceutical Statistics

By Alex Dmitrienko,Ajit C. Tamhane,Frank Bretz

ISBN-10: 1584889845

ISBN-13: 9781584889847

Useful Statistical methods for Addressing Multiplicity Issues
Includes useful examples from contemporary trials

Bringing jointly top statisticians, scientists, and clinicians from the pharmaceutical undefined, academia, and regulatory businesses, Multiple checking out difficulties in Pharmaceutical Statistics explores the speedily turning out to be region of a number of comparability examine with an emphasis on pharmaceutical functions. In every one bankruptcy, the specialist participants describe vital multiplicity difficulties encountered in pre-clinical and medical trial settings.

The booklet starts with a vast advent from a regulatory point of view to varieties of multiplicity difficulties that in most cases come up in confirmatory managed medical trials, prior to giving an summary of the innovations, rules, and tactics of a number of checking out. It then provides statistical equipment for reading scientific dose reaction stories that examine a number of dose degrees with a keep an eye on in addition to statistical equipment for studying a number of endpoints in scientific trials. After protecting gatekeeping systems for trying out hierarchically ordered hypotheses, the publication discusses statistical methods for the layout and research of adaptive designs and similar confirmatory speculation trying out difficulties. the ultimate bankruptcy specializes in the layout of pharmacogenomic reports according to demonstrated statistical rules. It additionally describes the research of information accrued in those reports, taking into consideration the varied multiplicity matters that occur.

This quantity explains find out how to resolve serious matters in a number of trying out encountered in pre-clinical and medical trial purposes. It offers the required statistical technique, in addition to examples and software program code to teach how one can use the equipment in perform.

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Multiple Testing Problems in Pharmaceutical Statistics (Chapman & Hall/CRC Biostatistics Series) by Alex Dmitrienko,Ajit C. Tamhane,Frank Bretz

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